Dampened enthusiasm

In a sudden spurt of enthusiasm this afternoon I decided to look at literary agents again.

My enthusiasm was dampened within minutes. So many agents all looking for 'new voices'. I should be excited at the prospect and filled with renewed hope. But.

I have written four novels one of which I self-published after twenty-six rejections. I've submitted the other novels to a variety of agents and publishers all with the same response: thank you but no. My voice isn't what they're looking for it seems.

Can I go through it all again? Each agent has very slightly different requirements so it's not as if I can mass mail them.

Or shall I go down the self-publishing route again?

I know This Time Next Year is good. As good as and better than many I read from libraries. 

Perhaps I'll feel more upbeat tomorrow.